| | Day | Time | | Opponent | Score | | Record |
| August |
| % | 21 | 1:00PM | @ | Carson-Newman College | W-18-25,18-25,30-28,16-25 | | |
| | 23 | 7:00PM | vs. | Lindsey Wilson | W-25-16,25-17,25-14 | | 1-0 |
| | 27 | 3:30PM | vs. | Black Hills State University | W-17-25,22-25,14-25 | | 2-0 |
| | Northwestern College Red Raider Classic |
| | | 7:30PM | vs. | Doane College | W-21-25,20-25,15-25 | | 3-0 |
| | Northwestern College Red Raider Classic |
| | 28 | 12:00PM | vs. | Biola University | W-18-25,14-25,25-18,25-23,12-15 | | 4-0 |
| | Northwestern College Red Raider Classic |
| | | 6:00PM | vs. | University of Great Falls | W-15-25,10-25,16-25 | | 5-0 |
| | Northwestern College Red Raider Classic |
| September |
 | 1 | 7:00PM | vs. | Shorter | W-25-9,25-22,23-25,25-13 | | 6-0 1-0 |
| | 7 | 7:00PM | @ | Brewton-Parker | W-12-25,15-25,13-25 | | 7-0 2-0 |
| | 10 | 3:30PM | vs. | SCAD Savannah | W-25-14,25-15,25-12 | | 8-0 |
| | Lee Invitational |
| | 11 | 9:30AM | vs. | Belhaven | W-25-17,25-8,25-8 | | 9-0 |
| | Lee Invitational |
| | | 4:15PM | vs. | Union University | W-25-12,25-13,25-18 | | 10-0 |
| | Lee Invitational |
| | 14 | 7:00PM | @ | Brenau | W-17-25,18-25,18-25 | | 11-0 3-0 |
| | 17 | 7:00PM | vs. | Emory University | W-25-21,25-23,25-19 | | 12-0 |
| | 22 | | vs. | Union College | W-25-16,25-12,25-15 | | 13-0 |
| | 25 | 1:00PM | vs. | Columbia College | W-25-14,25-15,25-16 | | 14-0 4-0 |
| | 28 | 7:00PM | @ | Southern Wesleyan | W-8-25,14-25,21-25 | | 15-0 5-0 |
| October |
| | 2 | 12:00PM | vs. | Mobile | W-26-24,25-15,25-13 | | 16-0 |
| | | 4:30PM | vs. | Georgetown College | W-25-18,25-23,25-24 | | 17-0 |
| | 5 | 7:00PM | @ | Shorter | W-27-25,18-25,21-25,25-23,10-15 | | 18-0 6-0 |
| | 8 | 7:00PM | @ | Emory University | W-20-25,19-25,25-21,17-25 | | 19-0 |
| | 12 | 7:00PM | vs. | Brenau | W-25-12,26-24,25-19 | | 20-0 7-0 |
| | 13 | 7:00PM | @ | Columbia College | W-25-23,10-25,14-25,20-25 | | 21-0 8-0 |
| | 15 | 11:00AM | vs. | Embry-Riddle | W-22-25,16-25,20-25 | | 22-0 |
| | SCAD Invitational Tournament |
| | | 3:00PM | vs. | Bellevue University | W-15-25,16-25,19-25 | | 23-0 |
| | SCAD Invitational Tournament |
| | 16 | 10:00AM | vs. | Texas at Brownsville | W-25-27,25-16,20-25,23-25 | | 24-0 |
| | SCAD Invitational Tournament |
| | 19 | 7:00PM | @ | Alabama-Huntsville | W-7-25,25-23,17-25,13-25 | | 25-0 |
| | 23 | 1:00PM | vs. | Brewton-Parker | W-25-12,25-19,25-23 | | 26-0 9-0 |
| | 27 | 6:00PM | vs. | Trevecca Nazarene | W-25-12,25-18,25-17 | | 27-0 |
| | 29 | 2:00PM | vs. | Taylor University | W-25-21,25-22,14-25,18-25,8-15 | | 28-0 |
| | Georgetown Boneyard Brawl |
| | | 6:00PM | vs. | Olivet Nazarene University | W-14-25,10-25,16-25 | | 29-0 |
| | Georgetown Boneyard Brawl |
| | 30 | 11:00AM | vs. | Walsh University | W-14-25,19-25,17-25 | | 30-0 |
| | Georgetown Boneyard Brawl |
| | | 3:00PM | vs. | Campbellsville University | W-18-25,29-27,16-25,12-25 | | 31-0 |
| | Georgetown Boneyard Brawl |
| November |
| | 5 | 7:00PM | vs. | Southern Wesleyan | W-25-10,25-16,25-16 | | 32-0 10-0 |
| | Lee finishes regular season 32-0 |
| | 12 | 12:00PM | vs. | Faulkner | W-25-15,25-21,25-13 | | 33-0 |
| | SSAC Tournament - Gulf Port, MS -Nov. 12-13 |
| | 13 | 11:00AM | vs. | Southern Wesleyan | W-12-25,12-25,21-25 | | 34-0 |
| | Semi-final round/SSAC Tournament |
| | | 7:00PM | vs. | Spring Hill | W-25-18,25-20,25-14 | | 35-0 |
| | 2010 SSAC Volleyball Championship @ Jeff Davis Campus, MGCCC, Gulfport, Miss. Nov. 12-13 |
| | 30 | 6:45PM | vs. | Briar Cliff University | W-25-22,27-25,25-20 | | 36-0 |
| | NAIA National/Pool Play |
| December |
| | 1 | 6:45PM | vs. | Southern Oregon University | W-20-25,19-25,25-22,25-16,15-13 | | 37-0 |
| | NAIA National/Pool Play |
| | 2 | 9:00PM | vs. | Embry-Riddle | W-25-18,25-20,23-25,25-20 | | 38-0 |
| | NAIA National/Pool Play |
| | 3 | 6:45PM | vs. | Lewis-Clark State College | W-21-25,25-24,21-25,14-25 | | 39-0 |
| | NAIA Championship Quarter-final Round |
| | 4 | 11:00AM | vs. | Columbia College | L-25-11,25-19,25-17 | | 39-1 |
| | NAIA Championship Semi-final Round |
